The effects of ursolic acid on cardiometabolic risk factors: a systematic review and meta-analysis.
Pegah RafieeNiloufar RasaeiMohammad Reza AminiReyhaneh RabieeZahra KalantarFatemeh SheikhhosseinMohammad GholizadehAzita HekmatdoostPublished in: Future cardiology (2024)
Aim: Ursolic acid (UA) has an important biological role in the fight against fat accumulation, insulin resistance, obesity and inflammation. Therefore, in the current review and meta-analysis work, we investigate the effects of UA (dosage range is 50.94 to 450 mg/day) on cardiometabolic risk factors. Materials & methods: After searching the studies up to February 2023, six articles were included in the study. Results: The pooled effect size showed that UA supplementation didn't significantly change body weight, body mass index, waist circumference, body fat percentage, lean body mass, systolic blood pressure, diastolic blood pressure, fasting blood glucose, insulin, triglyceride and high-density lipoprotein compared with control groups. Conclusion: UA supplementation had no significant effect on the cardiometabolic risk factors in adults.
Keyphrases
- blood pressure
- blood glucose
- risk factors
- body weight
- body mass index
- insulin resistance
- glycemic control
- high density
- type diabetes
- hypertensive patients
- adipose tissue
- weight gain
- metabolic syndrome
- left ventricular
- heart rate
- heart failure
- oxidative stress
- polycystic ovary syndrome
- high fat diet induced
- weight loss
- physical activity
- open label
- ejection fraction