Respiratory Syncytial Virus Infection: Its Propensity for Bacterial Coinfection and Related Mortality in Elderly Adults.
Raphael GodefroyAudrey Giraud-GatineauMarie-Thérèse JimenoSophie EdouardLine MeddebChristine ZandottiHervé ChaudetPhilippe ColsonDidier RaoultNadim CassirPublished in: Open forum infectious diseases (2020)
Respiratory syncytial virus (RSV) is an increasingly recognized cause of acute respiratory infection (ARI) in adults. We compared the crude in-hospital mortality of patients with RSV infection alone with that of patients with RSV-bacterial coinfection. Overall, 12 144 hospitalized patients with ARI were screened for RSV detection by polymerase chain reaction between February 2014 and April 2019. In total, 701 (5.8%) had a positive RSV result, including 85 (12.1%) with bacterial coinfection. RSV-bacterial coinfection was associated with an increase in crude in-hospital mortality in patients >65 years old (hazard ratio, 2.94; 95% CI, 1.30-6.60; P = .010). Optimized prevention and management strategies to reduce this burden are needed.
Keyphrases
- respiratory syncytial virus
- end stage renal disease
- newly diagnosed
- ejection fraction
- chronic kidney disease
- risk factors
- liver failure
- prognostic factors
- cardiovascular disease
- type diabetes
- patient reported outcomes
- hepatitis b virus
- patient reported
- respiratory failure
- acute respiratory distress syndrome
- real time pcr