Linezolid population pharmacokinetic model in plasma and cerebrospinal fluid among patients with tuberculosis meningitis.

Noha AbdelgawadSean WassermanMahmoud Tareq AbdelwahabAngharad DavisCari StekLubbe WiesnerJohn BlackGraeme MeintjesRobert J WilkinsonPaolo Denti

Published in: The Journal of infectious diseases (2023)

Linezolid was readily detected in CSF despite high-dose rifampicin co-administration. These findings support continued clinical evaluation of linezolid plus high-dose rifampicin for the treatment of TBM in adults.

Keyphrases

high dose
cerebrospinal fluid
mycobacterium tuberculosis
pulmonary tuberculosis
methicillin resistant staphylococcus aureus
low dose
stem cell transplantation
combination therapy
replacement therapy
antiretroviral therapy