An in silico-in vitro pipeline for drug cardiotoxicity screening identifies ionic pro-arrhythmia mechanisms.

Alexander P ClarkSiyu WeiDarshan KalolaTrine Krogh-MadsenDavid J Christini

Published in: British journal of pharmacology (2022)

We developed an in silico-in vitro pipeline that simultaneously identifies pro-arrhythmia risk and mechanism of ion channel-blocking drugs. The approach offers a new tool for evaluating cardiotoxicity during preclinical drug screening.

Keyphrases

genome wide
molecular docking
anti inflammatory
drug induced
adverse drug
catheter ablation
emergency department
gene expression
electronic health record