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Enhancing circadian clock function in cancer cells inhibits tumor growth.

Silke KiesslingLou Beaulieu-LarocheIan D BlumDominic LandgrafDavid K WelshKai-Florian StorchNathalie LabrecqueNicolas Cermakian
Published in: BMC biology (2017)
Here we demonstrated that the effects of dexamethasone on cell cycle and tumor growth are mediated by the tumor-intrinsic circadian clock. Thus, our work reveals that enhancing circadian clock function might represent a novel strategy to control cancer progression.
Keyphrases
  • cell cycle
  • cell proliferation
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  • low dose
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