Enhancing circadian clock function in cancer cells inhibits tumor growth.
Silke KiesslingLou Beaulieu-LarocheIan D BlumDominic LandgrafDavid K WelshKai-Florian StorchNathalie LabrecqueNicolas CermakianPublished in: BMC biology (2017)
Here we demonstrated that the effects of dexamethasone on cell cycle and tumor growth are mediated by the tumor-intrinsic circadian clock. Thus, our work reveals that enhancing circadian clock function might represent a novel strategy to control cancer progression.