Treatment Settings and Outcomes with Regorafenib and Trifluridine/Tipiracil at Third-Line Treatment and beyond in Metastatic Colorectal Cancer: A Real-World Multicenter Retrospective Study.
Carlo SignorelliMaria Alessandra CalegariMichele BassoAnnunziato AngheloneJessica LucchettiAlessandro MinelliLorenzo AngottiIna Valeria ZurloMarta SchirripaMario Giovanni ChilelliCristina MorelliEmanuela Dell'AquilaAntonella CosimatiDonatello GemmaMarta RibelliAlessandra EmilianiDomenico Cristiano CorsiGiulia ArriviFederica MazzucaFederica ZorattoMaria Grazia MorandiFiorenza SantamariaRosa SaltarelliEnzo Maria RuggeriPublished in: Current oncology (Toronto, Ont.) (2023)
The R/T sequence resulted in a significantly longer OS and PFS and improved disease control compared with the reverse sequence. R and T given not sequentially have similar impacts on survival. More data are needed to define the best sequence and to explore the efficacy of sequential (T/R or R/T) treatment combined with molecular-targeted drugs.