Histamine, mast cell tryptase and post-exercise hypotension in healthy and collapsed marathon runners.
Iain T ParsonsM J StaceyL FacontiN HillJ O'HaraE WalterB FarukhR McNallyH SharpA PattenR GrimaldiN GallP ChowienczykD R WoodsPublished in: European journal of applied physiology (2021)
These data support the hypothesis that mast cell degranulation is a vasodilatory mechanism underlying PEH and exercise associated collapse. The magnitude of PEH is inversely proportional to the muscle mass and enhanced by concomitant body heating.