Quantification of Calcyclin and Heat Shock Protein 90 in Sera from Women with and without Preeclampsia by Mass Spectrometry.
Coşkun GüzelCaroline B van den BergJohannes J DuvekotChristoph StinglThierry P P van den BoschMarcel van der WeidenEric A P SteegersRegine P M Steegers-TheunissenTheo M LuiderPublished in: Proteomics. Clinical applications (2018)
Both interacting proteins calcyclin and heat shock protein 90 are notably changed in preeclamptic patients compared to controls. Calcyclin is already decreased before the onset of preeclampsia in the second trimester and HSP90 is strongly increased in the third trimester. This suggests that these proteins may play a role in the pathogenesis of preeclampsia and ought to be investigated in large cohort studies as molecular biomarkers.
Keyphrases
- heat shock protein
- pregnancy outcomes
- early onset
- heat shock
- mass spectrometry
- end stage renal disease
- ejection fraction
- newly diagnosed
- chronic kidney disease
- preterm birth
- peritoneal dialysis
- pregnant women
- liquid chromatography
- prognostic factors
- high resolution
- gestational age
- high performance liquid chromatography
- gas chromatography