Causal relationship between inflammatory factors and cerebral small vessel disease: Univariate, multivariate, and summary-data-based mendelian randomization analysis.
Tian-Ci QiaoHao-Yu TianShi-Zhe ShanLi-Li ShanZheng-Yu PengJia KeMeng-Ting LiYang WuYan HanPublished in: Brain and behavior (2024)
According to MR and SMR analysis, higher levels of TRAIL increased the risk of SVS by upregulating gene expression of KNG1 in brain cortex tissues. In addition, protective effects of E-selectin and IL-3a levels on WMPVS were regulated by increased DNA methylation of gene ABO in blood tissue.
Keyphrases
- gene expression
- dna methylation
- genome wide
- oxidative stress
- magnetic resonance
- copy number
- functional connectivity
- subarachnoid hemorrhage
- magnetic resonance imaging
- electronic health record
- resting state
- computed tomography
- data analysis
- machine learning
- multiple sclerosis
- transcription factor
- brain injury
- artificial intelligence