LPS-Induced Inflammation Affects Midazolam Clearance in Juvenile Mice in an Age-Dependent Manner.

Yi ZhengPan-Pan YeYue ZhouSu-Ying WuXi-Ting LiuBin DuBo-Hao TangMin KanAi-Qing NieRui YinMeng WangGuo-Xiang HaoLin-Lin SongXin-Mei YangXin HuangLe-Qun SuWen-Qi WangJohn van den AnkerWei Zhao

Published in: Journal of inflammation research (2021)

Both inflammation and ontogeny have an essential role in CYP3A activity in mice. The effect of LPS-induced systemic inflammation on midazolam clearance in mice is dependent on postnatal age.

Keyphrases

lps induced
inflammatory response
high fat diet induced
oxidative stress
preterm infants
type diabetes
insulin resistance
metabolic syndrome
skeletal muscle