T-Cell Characteristics Impact Response and Resistance to T-Cell-Redirecting Bispecific Antibodies in Multiple Myeloma.
Christie P M VerkleijChloe A O'NeillMarloes E C BroekmansKristine A FrerichsWassilis S C BruinsCarolien DuetzSandy KruyswijkS Rubina BaglioSheri SkergetRocio Montes de OcaSonja ZweegmanRaluca I VeronaTuna MutisNiels W C J van de DonkPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2024)
Primary resistance is characterized by a low T-cell/multiple myeloma cell ratio and Treg-driven immunosuppression, whereas reduced T-cell fitness due to continuous BsAb-mediated T-cell activation may contribute to the development of acquired resistance.