Distinct Reactivity Modes of a Copper Hydride Enabled by an Intramolecular Lewis Acid.

Emily E NorwineJohn J Kiernicki Matthias Zeller Nathaniel K Szymczak

Published in: Journal of the American Chemical Society (2022)

We disclose a 1,4,7-triazacyclononane (TACN) ligand featuring an appended boron Lewis acid. Metalation with Cu(I) affords a series of tetrahedral complexes including a boron-capped cuprous hydride. We demonstrate distinct reactivity modes as a function of chemical oxidation: hydride transfer to CO 2 in the copper(I) state and oxidant-induced H 2 evolution as well as alkyne reduction.

Keyphrases

high glucose
hydrogen peroxide
endothelial cells
nitric oxide
electron transfer
energy transfer