Acremosides A-G, Sugar Alcohol-Conjugated Acyclic Sesquiterpenes from a Sponge-Derived Acremonium Species.
Xiaomeng HaoShasha LiJianrui LiGuiyang WangJiao LiZonggen PengMaoluo GanPublished in: Journal of natural products (2024)
Seven new sugar alcohol-conjugated acyclic sesquiterpenes, acremosides A-G ( 1 - 7 ), were isolated from the cultures of the sponge-associated fungus Acremonium sp. IMB18-086 cultivated with heat-killed Pseudomonas aeruginosa . The structures were determined by comprehensive analyses of 1D and 2D NMR spectroscopic data. The relative configurations were established by J -based configuration analysis and acetonide derivatization. The absolute configurations were elucidated by the Mosher ester method and ECD calculations. The structures of acremosides E-G ( 5 - 7 ) featured the linear sesquiterpene skeleton with a tetrahydrofuran moiety attached to a sugar alcohol. Acremosides A ( 1 ) and C-E ( 3 - 5 ) showed significant inhibitory activities against hepatitis C virus (EC 50 values of 4.8-8.8 μM) with no cytotoxicity (CC 50 of >200 μM).
Keyphrases
- hepatitis c virus
- pseudomonas aeruginosa
- high resolution
- alcohol consumption
- photodynamic therapy
- magnetic resonance
- cystic fibrosis
- electronic health record
- molecular dynamics
- molecular docking
- heat stress
- density functional theory
- drug resistant
- deep learning
- staphylococcus aureus
- liquid chromatography
- gas chromatography
- acinetobacter baumannii
- multidrug resistant
- hiv infected
- neural network
- monte carlo