Transcription factors NFIA and NFIB induce cellular differentiation in high-grade astrocytoma.
Kok-Siong ChenCaitlin R BridgesZorana LyntonJonathan W C LimBrett W StringerRevathi RajagopalKum-Thong WongDharmendra GanesanHany AriffinBryan W DayLinda J RichardsJens BuntPublished in: Journal of neuro-oncology (2019)
Our findings indicate that both NFIA and NFIB may have an endogenous pro-differentiative function in astrocytomas, similar to their role in normal astrocyte differentiation. Overall, our study establishes a basis for further investigation of targeting NFI-mediated differentiation as a potential differentiation therapy.