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Circulating Myeloperoxidase (MPO)-DNA complexes as marker for Neutrophil Extracellular Traps (NETs) levels and the association with cardiovascular risk factors in the general population.

Samantha J DonkelSirwan K L DarweeshM Arfan IkramMoniek P M de Maat
Published in: PloS one (2021)
Older age, a history of coronary heart disease, the use of lipid-lowering drugs and higher HDL-cholesterol are weakly correlated with lower plasma levels of NETs. These findings show that the effect of CVD risk factors on NETs levels in a general population is only small and may not be of clinical relevance. This supports that NETs may play a more important role in an acute phase of disease than in a steady state situation.
Keyphrases
  • cardiovascular risk factors
  • risk factors
  • metabolic syndrome
  • circulating tumor
  • physical activity
  • community dwelling