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Clinical impact of selumetinib on pediatric elephantiasis neuromatosa.

Kristina MichaudSara E Ortiz-RomeroOlivia JuarezJulie Voeller
Published in: Pediatric dermatology (2022)
Elephantiasis neuromatosa (EN) is a rare and extreme form of plexiform neurofibroma in patients with neurofibromatosis type 1 (NF1). EN is often associated with significant morbidity and remains difficult to treat. We present a case of an 11-year-old female with NF1 whose thoracolumbar plexiform neurofibroma and lower extremity EN exhibited clinical improvement from treatment with selumetinib, a selective MEK inhibitor.
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