Whole Blood Targeted Bisulfite Sequencing and Differential Methylation in the C6ORF10 Gene of Patients with Rheumatoid Arthritis.

Vidyanand Anaparti Prasoon Agarwal Irene Smolik Neeloffer Mookherjee Hani El-Gabalawy

Published in: The Journal of rheumatology (2019)

Our results confirm the presence of differential methylation at specific gene loci within the MHC region of INA patients with RA. These epigenetic signatures may precede disease onset, or alternatively, may be a result of developing RA.

Keyphrases

genome wide
dna methylation
copy number
rheumatoid arthritis
gene expression
disease activity
ankylosing spondylitis
genome wide identification
single cell
cancer therapy
systemic lupus erythematosus
interstitial lung disease
systemic sclerosis
drug delivery