RFX6 haploinsufficiency predisposes to diabetes through impaired beta cell function.

Hazem Ibrahim Diego Balboa Jonna Saarimäki-Vire Hossam Montaser Oleg Dyachok Per-Eric Lund Muhmmad Omar-Hmeadi Jouni A Kvist Om Prakash Dwivedi Väinö Lithovius Tom Barsby Vikash Chandra Solja EurolaJarkko UstinovTiinamaija Tuomi Päivi J Miettinen Sebastian Barg Anders Tengholm Timo Otonkoski

Published in: Diabetologia (2024)

Ultra-deep bulk RNA-seq data for pancreatic differentiation stages 3, 5 and 7 of H1 RFX6 genotypes are deposited in the Gene Expression Omnibus database with accession code GSE234289. Original western blot images are deposited at Mendeley ( https://data.mendeley.com/datasets/g75drr3mgw/2 ).

Keyphrases

rna seq
single cell
gene expression
electronic health record

type diabetes
big data
cardiovascular disease
dna methylation

deep learning
south africa
convolutional neural network
high resolution

optical coherence tomography
data analysis
weight loss