SKO1 deficiency extends chronological lifespan in Saccharomyces cerevisiae.

Koji MasumuraSachi MatsukamiKumiko YonekitaMuneyoshi KanaiKazunori KumeDai HirataMasaki Mizunuma

Published in: Bioscience, biotechnology, and biochemistry (2019)

Sko1 plays a key role in the control of gene expression by osmotic and oxidative stress in yeast. We demonstrate that the decrease in chronological lifespan (CLS) of hog1Δ cells was suppressed by SKO1 deletion. sko1Δ single mutant cells were shown to have a longer CLS, thus implicating Sko1 in the regulation of their CLS.

Keyphrases

induced apoptosis
saccharomyces cerevisiae
gene expression
oxidative stress
cell cycle arrest
endoplasmic reticulum stress
dna methylation
dna damage
cell death
pi k akt
smoking cessation
heat shock
cell wall