Oral pyogenic granulomas show MAPK/ERK signaling pathway activation, which occurs independently of BRAF, KRAS, HRAS, NRAS, GNA11, and GNA14 mutations.

Thaís Dos Santos Fontes PereiraLarissa Stefhanne Damasceno de AmorimNubia Braga PereiraJéssica Gardone VitórioFilipe Fideles Duarte-AndradeLetícia Martins GuimarãesMarina Gonçalves DinizCarolina Cavaliéri Gomes Hélder Antônio Rebelo Pontes

Published in: Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology (2019)

Although oral PG shows MAPK/ERK pathway activation, the driver molecular event remains to be elucidated.

Keyphrases

signaling pathway
pi k akt
wild type
induced apoptosis
epithelial mesenchymal transition
cell proliferation
oxidative stress
endoplasmic reticulum stress