Gene Expression Profiling of Bronchoalveolar Lavage Cells Preceding a Clinical Diagnosis of Chronic Lung Allograft Dysfunction.

S Samuel WeigtXiaoyan WangVyacheslav PalchevskiyAric L GregsonNaman PatelAriss DerHovanessianMichael Y ShinoDavid M SayahShirin BirjandiJoseph P LynchRajan SaggarAbbas ArdehaliDavid J RossScott M PalmerDavid ElashoffJohn A Belperio

Published in: PloS one (2017)

These findings suggest that a pathobiology, similar to AR, precedes a clinical diagnosis of CLAD. A larger prospective investigation of the BAL cell pellet transcriptome as a biomarker for CLAD risk stratification is warranted.

Keyphrases

gene expression
single cell
induced apoptosis
dna methylation
rna seq
cell cycle arrest
cell therapy
stem cells
signaling pathway
endoplasmic reticulum stress
cell death
drug induced