Type 2 Diabetes Mellitus Facilitates Shift of Adipose-Derived Stem Cells Ex Vivo Differentiation toward Osteogenesis among Patients with Obesity.
Margarita Yu AgarevaIurii StafeevSvetlana MichurinaIgor A SklyanikEkaterina ShestakovaElizaveta RatnerXiang HuMikhail MenshikovMarina ShestakovaYelena ParfyonovaPublished in: Life (Basel, Switzerland) (2022)
We suggest that T2DM-associated cellular senescence can cause ADSC differentiation to shift toward osteogenesis, the impaired formation of new fat depots in adipose tissue, and the development of insulin resistance. The balance between ADSC adipo- and osteogenesis commitment is crucial for the determination of the metabolic fate of patients and their adipose tissue.
Keyphrases
- adipose tissue
- insulin resistance
- high fat diet
- end stage renal disease
- high fat diet induced
- glycemic control
- metabolic syndrome
- type diabetes
- ejection fraction
- polycystic ovary syndrome
- skeletal muscle
- newly diagnosed
- prognostic factors
- bone regeneration
- chronic kidney disease
- peritoneal dialysis
- dna damage
- cardiovascular disease
- solid phase extraction
- endothelial cells
- oxidative stress