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Chrysophanol exerts neuroprotective effects via interfering with endoplasmic reticulum stress apoptotic pathways in cell and animal models of Alzheimer's disease.

Xinquan LiYaxun ChengYunpeng QinHuawu GaoGuangyun WangHang SongYan WangBiao Cai
Published in: The Journal of pharmacy and pharmacology (2021)
This study revealed a novel mechanism through which CHR plays a neuroprotective role by regulating ERS when it comes to the therapy of AD.
Keyphrases
  • endoplasmic reticulum stress
  • induced apoptosis
  • single cell
  • cell therapy
  • cognitive decline
  • stem cells
  • mesenchymal stem cells
  • cerebral ischemia
  • blood brain barrier
  • replacement therapy