Synthesis of Spirocyclic Pyrrolidines: Advanced Building Blocks for Drug Discovery.
Bohdan A ChalykMaryna V ButkoOksana O YanshynaKonstantin S GavrilenkoTetiana V DruzhenkoPavel K MykhailiukPublished in: Chemistry (Weinheim an der Bergstrasse, Germany) (2017)
In the context of drug discovery, novel spirocyclic pyrrolidines have been synthesized in two steps from common three- to seven-membered-ring (hetero)alicyclic ketones. The key transformation is a reaction between an electron-deficient exocyclic alkene and an in situ generated N-benzyl azomethine ylide. The developed method has been used to synthesize the central diamine core of the known antibacterial agents Sitafloxacin and Olamufloxacin.