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Chitosan alleviates ovarian aging by enhancing macrophage phagocyte-mediated tissue homeostasis.

Hui-Hui ShenXin-Yan ZhangNan LiuYang-Yang ZhangHui-Hua WuFeng XieWen-Jun WangMing-Qing Li
Published in: Immunity & ageing : I & A (2024)
Aging ovarian is characterized by an accumulation of aging and apoptotic granulosa cells, an inflammatory response and macrophage phagocytosis dysfunction. In turn, impaired phagocytosis of macrophage contributes to insufficient clearance of aging and apoptotic granulosa cells and the increased risk of DOR. Additionally, LMWC emerges as a potential therapeutic strategy for age-related ovarian dysfunction.
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