The in vitro anti-inflammatory activity of N-antipyrine-3,4-dichloromaleimide derivatives is due to an immunomodulatory effect on cytokines environment.
Eduarda FratoniLais Cristina TheindlJulia Salvan da RosaMarcus Vinicius Pereira Dos Santos NascimentoTatiana da Rosa Guimarães MacielFátima de Campos-BuzziEduardo Monguilhott DalmarcoPublished in: Immunopharmacology and immunotoxicology (2022)
In conclusion, these two compounds present a significant and unusual anti-inflammatory mechanism (increasing the production of anti-inflammatory mediators). They are therefore considered promising prototypes for the development of new anti-inflammatory drugs with immunomodulatory characteristics.
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