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Expression analysis of HMGB1 in histological samples of malignant pleural mesothelioma.

Eltjona RrapajElena TrisoliniLuca BerteroMichela SalvoRossella IndellicatoSilvano AndornoJose M Garcia-ManteigaOttavio RenaRenzo L Boldorini
Published in: Histopathology (2018)
These findings indicate that HMGB1 may be a useful prognostic biomarker in MPM when detected by immunohistochemistry. Conversely, as it is also expressed in normal and reactive mesothelial cells, HMGB1 cannot be considered a diagnostic biomarker in histological samples of mesothelioma.
Keyphrases
  • induced apoptosis
  • cell cycle arrest
  • oxidative stress
  • signaling pathway