Expression analysis of HMGB1 in histological samples of malignant pleural mesothelioma.

Eltjona RrapajElena TrisoliniLuca BerteroMichela SalvoRossella IndellicatoSilvano AndornoJose M Garcia-ManteigaOttavio RenaRenzo L Boldorini

Published in: Histopathology (2018)

These findings indicate that HMGB1 may be a useful prognostic biomarker in MPM when detected by immunohistochemistry. Conversely, as it is also expressed in normal and reactive mesothelial cells, HMGB1 cannot be considered a diagnostic biomarker in histological samples of mesothelioma.

Keyphrases

induced apoptosis
cell cycle arrest
oxidative stress
signaling pathway