Intra-articular injection of triamcinolone acetonide sustains macrophage levels and aggravates osteophytosis during degenerative joint disease in mice.
Mauricio N Ferrao BlancoYvonne M Bastiaansen JenniskensNicole KopsAthina ChavliRoberto NarcisiSander M BotterPieter J M LeenenGerjo J V M van OschNiamh FahyPublished in: British journal of pharmacology (2022)
Intra-articular injection of TAA increases long-term synovial macrophage numbers and osteophytosis. Our findings suggest that TAA accentuates the progression of osteoarthritis-associated features when applied to an acutely inflamed knee.