HBeAg-negative single hepatocyte analysis shows transcriptional silencing and slow decay of infected cells with treatment.

Chloe L ThioMaraake TaddeseYasmeen SaadKristina ZamboRuy M RibeiroTanner GruddaMark S SulkowskiRichard K SterlingYang ZhangEric D YoungHyon S HwangAshwin Balagopal

Published in: The Journal of infectious diseases (2023)

In HBeAg-negative CHB on NUCs, the negligible decline in infected hepatocytes is similar to HBeAg-positive CHB, supporting the need for more potent therapeutics to achieve functional cure.

Keyphrases

hepatitis b virus
induced apoptosis
liver injury
gene expression
transcription factor
cell cycle arrest
endoplasmic reticulum stress
anti inflammatory
combination therapy
oxidative stress
heat shock