MerTK inhibition decreases immune suppressive glioblastoma-associated macrophages and neoangiogenesis in glioblastoma microenvironment.
Yu-Ting SuMadison ButlerMeili ZhangWei ZhangHua SongLee HwangAndy D TranRyan E BashAllison N SchorzmanYing PangGuangyang YuWilliam C ZamboniXiaodong WangStephen V FryeChristopher Ryan MillerDragan MaricMasaki TerabeMark R GilbertHenry Shelton Earp IiiJing WuPublished in: Neuro-oncology advances (2020)
Our findings suggest that MRX-2843 has a therapeutic benefit via promoting GAM polarization away from immunosuppressive condition, inhibiting neoangiogenesis in the glioblastoma microenvironment and inducing tumor cell death.