The derepression of transposable elements in lung cells is associated with the inflammatory response and gene activation in idiopathic pulmonary fibrosis.
Mahboubeh R RostamiMartina BradicPublished in: Mobile DNA (2021)
Based on our findings, we propose that TE derepression plays an important role in the regulation of gene expression and can also prompt both the recruitment of inflammatory processes and the disruption of the immunological balance, which can lead to chronic inflammation in IPF.
Keyphrases
- idiopathic pulmonary fibrosis
- gene expression
- inflammatory response
- oxidative stress
- induced apoptosis
- interstitial lung disease
- cell cycle arrest
- dna methylation
- genome wide
- lipopolysaccharide induced
- copy number
- cell death
- endoplasmic reticulum stress
- toll like receptor
- genome wide identification
- cell proliferation
- systemic sclerosis
- drug induced