Clinical Features and Outcomes of Bloodstream Infections Caused by New Delhi Metallo-β-Lactamase-Producing Enterobacterales During a Regional Outbreak.

Marco FalconeGiusy TiseoAlberto AntonelliCesira GiordanoVincenzo Di PilatoPietro BertolucciEva Maria ParisioAlessandro LeonildiNoemi AiezzaIlaria BaccaniEnrico TagliaferriLorenzo RighiSilvia ForniSpartaco SaniMaria Teresa MechiFilippo PieralliSimona BarniniGian Maria RossoliniFrancesco Menichetti

Published in: Open forum infectious diseases (2020)

Limited data about New Delhi metallo-β-lactamase (NDM) bacteremia are available. Blood isolates from 40 patients with NDM bacteremia were studied for antibiotic susceptibility and whole-genomic sequencing. NDM bacteremia has high 30-day mortality. In most cases, aztreonam-avibactam is active in vitro. Ceftazidime-avibactam plus aztreonam may represent a feasible therapeutic option.

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