A Randomized Phase II Study of Coexpression Extrapolation (COXEN) with Neoadjuvant Chemotherapy for Bladder Cancer (SWOG S1314; NCT02177695).
Thomas W FlaigCatherine M TangenSiamak DaneshmandAjjai AlvaSeth P LernerM Scott LuciaDavid J McConkeyDan TheodorescuAmir GoldkornMatthew I MilowskyRick BangsGary R MacVicarBruno R BastosJared S FowlesDaniel L GustafsonMelissa PletsIan M ThompsonPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2021)
Treatment-specific COXEN scores were not significantly predictive for response to individual chemotherapy treatment. The COXEN GEM GC score was significantly associated with downstaging in the pooled arms. Additional biomarker development is planned.