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Expanding the spectrum of low-grade sinonasal adenocarcinoma with biphasic seromucinous differentiation and activating HRAS/AKT1 mutations.

Viktoria S HadnagyMeike KörnerMatthias RösslePatrick DubachGunther PabstAlexandra KotulovaStefan WederRobert SeifertElisabeth J RushingDavid HolzmannMartin HüllnerSandra N FreibergerNiels J Rupp
Published in: Histopathology (2024)
This study further corroborates a distinct biphasic low-grade neoplasm of the sinonasal tract with seromucinous differentiation. Although morphological and molecular features overlap with salivary gland epithelial-myoepithelial carcinoma, several arguments favour categorising these tumours within the spectrum of LGSNAC.
Keyphrases
  • low grade
  • high grade
  • signaling pathway
  • squamous cell carcinoma
  • cell proliferation
  • radiation therapy
  • locally advanced