Effects of senolytic drugs on human mesenchymal stromal cells.

Clara GrezellaEduardo Fernandez-RebolloJulia FranzenMónica Sofia Ventura FerreiraFabian BeierWolfgang Wagner

Published in: Stem cell research & therapy (2018)

Of the four tested drugs, only ABT-263 revealed a senolytic effect in human MSCs-and even treatment with this compound did not rejuvenate MSCs with regard to telomere length or epigenetic senescence signature. It will be important to identify more potent senolytic drugs to meet the high hopes for regenerative medicine.

Keyphrases

endothelial cells
mesenchymal stem cells
induced pluripotent stem cells
gene expression
dna methylation
bone marrow
dna damage
umbilical cord
single cell
oxidative stress
drug induced
anti inflammatory
smoking cessation