Corylifol A ameliorates muscle atrophy by inhibiting TAOK1/p38-MAPK/FoxO3 pathway in cancer cachexia.

Ruiqin ZhangQiang ShenYueping WangXue DengJialing FanXiaofan GuMeng FanKun WeiChun-Ru ChengWei-Dong ZhangXiong-Wen Zhang Xuan Liu

Published in: Journal of cachexia, sarcopenia and muscle (2023)

CYA ameliorates cancer cachexia muscle atrophy by decreasing both UPS degradation and autophagy. The ameliorating effects of CYA on muscle atrophy might be based on its binding with TAOK1 and inhibiting the TAOK1/p38-MAPK/FoxO3 pathway.

Keyphrases

signaling pathway
papillary thyroid
skeletal muscle
squamous cell
transcription factor
pi k akt
cell death
endoplasmic reticulum stress
cell proliferation