Pharmacokinetic-pharmacodynamic modelling and simulation of methotrexate dosing in patients with rheumatoid arthritis.

Jiun Ming Tan Richard N Upton David J R Foster Susanna M Proudman Arghya Chattopadhyay Michael D Wiese

Published in: British journal of clinical pharmacology (2024)

A loading dose regimen was more likely to achieve higher ery-MTX-PG concentration and better therapeutic response after 4 weeks of methotrexate treatment.

Keyphrases

high dose
low dose
smoking cessation