PCSK6 and Survival in Idiopathic Pulmonary Fibrosis.
Justin M OldhamRichard J AllenJose M Lorenzo-SalazarPhilip L MolyneauxShwu-Fan MaChitra JosephJohn S KimBeatriz Guillen-GuioTamara Hernández-BeeftinkJonathan A KropskiYong HuangCathryn T LeeAyodeji AdegunsoyeJanelle Vu PugashettiAngela L LinderholmVivian VoMary E StrekJonathan JouAdrian Muñoz-BarreraLuis A Rubio-RodriguezRichard HubbardNik HiraniMoira K B WhyteSimon HartAndrew G NicholsonLisa LancasterHelen ParfreyDoris RasslWilliam WallaceEleanor ValenziYingze ZhangJosyf MychaleckyjAmy StockwellNaftali KaminskiPaul J WoltersMaria Molina-MolinaNicholas E BanovichWilliam A FahyFernando J MartinezIan P HallMartin D TobinToby M MaherTimothy S BlackwellBrian L YaspanR Gisli JenkinsCarlos FloresLouise V WainImre NothPublished in: American journal of respiratory and critical care medicine (2023)
We identified four novel variants associated with IPF survival, including one in PCSK6 that reached genome-wide significance. Downstream analyses suggested that PCSK6 protein plays a potentially important role in IPF progression. This article is open access and distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/).