HO-1/CO Maintains Intestinal Barrier Integrity through NF-κB/MLCK Pathway in Intestinal HO-1-/- Mice.

Zhenling ZhangLijing ZhangQiuping ZhangBojia LiuFang LiYi XinZhijun Duan

Published in: Oxidative medicine and cellular longevity (2021)

HO-1/CO maintains intestinal barrier integrity through the NF-κB/MLCK pathway. Therefore, the intestinal HO-1/CO-NF-κB/MLCK system is a potential therapeutic target for diseases with a leaky gut.

Keyphrases

pi k akt
signaling pathway
lps induced
oxidative stress
nuclear factor
inflammatory response
immune response
metabolic syndrome
risk assessment