Direct Ingestion of Oxidized Red Blood Cells (Efferocytosis) by Hepatocytes.

Chaowen ZhengSiyuan LiHuanran LyuCheng ChenJohannes MuellerAnne DropmannSeddik HammadSteven DooleySongqing HeSebastian Mueller

Published in: Hepatic medicine : evidence and research (2024)

We here demonstrate that hepatocytes can directly ingest and degrade oxidized RBCs through efferocytosis, a process that can be also triggered by ethanol, heme and bilirubin. Our findings are highly suggestive for a novel mechanism of hepatic iron overload in ALD patients.

Keyphrases

red blood cell
end stage renal disease
ejection fraction
newly diagnosed
chronic kidney disease
prognostic factors
liver injury
low density lipoprotein
patient reported outcomes