FAM83H-AS1 is a noncoding oncogenic driver and therapeutic target of lung adenocarcinoma.

Siwei WangChencheng HanTongyan LiuZhifei MaMan-Tang QiuJie WangQingjun YouXiufen ZhengWeizhang XuWenjia XiaYoutao XuJingwen HuLin XuRong Yin

Published in: Clinical and translational medicine (2021)

Our work demonstrates that FAM83H-AS1 is a noncoding oncogenic driver that inhibits LUAD apoptosis via the FAM83H-AS1-HNRNPK-RAB8B/RAB14 axis, which highlights the importance and potential roles that FAM83H-AS1 may serve as a novel therapeutic target for LUAD.

Keyphrases

transcription factor
oxidative stress
cell death
cell cycle arrest