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Architectural underpinnings of stochastic intergenerational homeostasis.

Kunaal JoshiCharles S WrightRudro R BiswasSrividya Iyer-Biswas
Published in: Physical review. E (2024)
Living systems are naturally complex and adaptive and offer unique insights into the strategies for achieving and sustaining stochastic homeostasis in different conditions. Here we focus on homeostasis in the context of stochastic growth and division of individual bacterial cells. We take advantage of high-precision long-term dynamical data that have recently been used to extract emergent simplicities and to articulate empirical intra- and intergenerational scaling laws governing these stochastic dynamics. From these data, we identify the core motif in the mechanistic coupling between division and growth, which naturally yields these precise rules, thus also bridging the intra- and intergenerational phenomenologies. By developing and utilizing techniques for solving a broad class of first-passage processes, we derive the exact analytic necessary and sufficient condition for sustaining stochastic intergenerational cell-size homeostasis within this framework. Furthermore, we provide predictions for the precision kinematics of cell-size homeostasis and the shape of the interdivision time distribution, which are compellingly borne out by the high-precision data. Taken together, these results provide insights into the functional architecture of control systems that yield robust yet flexible stochastic homeostasis.
Keyphrases
  • electronic health record
  • single cell
  • big data
  • oxidative stress
  • induced apoptosis
  • stem cells
  • bone marrow
  • signaling pathway
  • cell cycle arrest
  • anti inflammatory
  • artificial intelligence
  • pi k akt