Astrocytic CREB in nucleus accumbens promotes susceptibility to chronic stress.

Leanne M HoltTrevonn M GylesEric M PariseAngelica Minier-ToribioTamara MarkovicMatthew RiveraSzu-Ying YehEric J Nestler

Published in: bioRxiv : the preprint server for biology (2024)

Together, our data demonstrate that the astrocyte transcriptome responds robustly to CSDS and, for the first time, that transcriptional regulation in astrocytes contributes to depressive-like behaviors. A better understanding of transcriptional regulation in astrocytes may reveal unknown molecular mechanisms underlying neuropsychiatric disorders.

Keyphrases

genome wide
single cell
stress induced
rna seq
electronic health record
bipolar disorder
gene expression
big data
dna methylation
single molecule