Temporal determinants of tumour response to neoadjuvant rectal radiotherapy.
Kendrick KooRachel WardRyan L SmithJeremy RubenPeter W G CarneHany ElsalehPublished in: PloS one (2021)
There was no observed benefit of chronomodulated radiotherapy in our cohort of rectal cancer patients. Review of the literature and meta-analysis confirms the benefit of delayed surgery, with a plateau in complete response rates at approximately 60-days between completion of radiotherapy and surgery. In our cohort, time to surgery for the majority of our patients lay along this plateau and this may be a more dominant factor in determining response to neoadjuvant therapy, obscuring any effects of chronomodulation on tumour response. We would recommend surgery be performed between 8 and 11 weeks after completion of neoadjuvant radiotherapy in patients with locally advanced rectal cancer.
Keyphrases
- locally advanced
- rectal cancer
- neoadjuvant chemotherapy
- minimally invasive
- coronary artery bypass
- phase ii study
- squamous cell carcinoma
- radiation therapy
- end stage renal disease
- surgical site infection
- early stage
- clinical trial
- chronic kidney disease
- ejection fraction
- peritoneal dialysis
- radiation induced
- bone marrow
- patient reported outcomes
- lymph node
- mesenchymal stem cells
- atrial fibrillation
- smoking cessation
- patient reported