Two-Year Treatment With Metformin During Puberty Does Not Preserve β-Cell Function in Youth With Obesity.
Megan M KelseyAllison HilkinLaura PyleCameron SevernKristina UtzschneiderRachael E Van PeltPhilip S ZeitlerKristen J NadeauPublished in: The Journal of clinical endocrinology and metabolism (2021)
Two years of metformin treatment in obese youth during puberty improved BMI and body fat, but not Si or β-cell function. Of note, high DI in early puberty may be predictive of later decline in DI. Further studies are needed to develop strategies for preservation of β-cell function in youth at risk for type 2 diabetes.