Methodological challenges when evaluating potential off-label prescribing of drugs using electronic health care databases: A case study of dabigatran etexilate in Europe.

Miguel Cainzos-AchiricaCristina Varas-LorenzoJesper HallasJoelle AsmarEstel PlanaLotte RasmussenGeoffray BizouardJoan FornsMaja HellfritzschKristina ZintSusana Perez-GutthannManel Pladevall-Vila

Published in: Pharmacoepidemiology and drug safety (2018)

Estimates of potential off-label use should be interpreted cautiously due to limitations in available information. In this context, CPRD HES-linkable estimates are likely to be the most accurate.

Keyphrases

healthcare
primary care
atrial fibrillation
human health
high resolution
emergency department
risk assessment
machine learning
big data
social media
adverse drug