Are Circulating Immune Cells a Determinant of Pancreatic Cancer Risk? A Prospective Study Using Epigenetic Cell Count Measures.
Verena A KatzkeCharlotte Le CornetRayaan MahfouzBianca BrauerTheron JohnsonFrederico CanzianVinciane ReboursMarie-Christine Boutron-RuaultGianluca SeveriMatthias Bernd SchulzeAnja OlsenAnne TjønnelandKim OvervadMarta Crous-BouEsther Molina-MontesPilar AmianoJosé María HouertaEva ArdanazAurora Perez-CornagoGiovanna MasalaValeria Maria PalaRosario TuminoCarlotta SacerdoteSalvatore PanicoBas Bueno-de-MesquitaRoel C H VermeulenMalin SundOskar FranklinSofia ChristakoudiLaure DossusElisabete WeiderpassSven OlekRudolf KaaksPublished in: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology (2021)
We have shown, for the first time, that increased relative counts of regulatory T cells and lower relative counts of CD8+, cytotoxic T cells may be associated with pancreatic cancer risk or relatively late-stage tumor development.See related commentary by Michaud and Kelsey, p. 2176.