Seven-chain adaptive immune receptor repertoire analysis in rheumatoid arthritis reveals novel features associated with disease and clinically relevant phenotypes.

Adrià AteridoMaría López-LasantaFrancisco BlancoAntonio Juan-MasMaría Luz García-VivarAlba ErraCarolina Pérez-GarcíaSimón Ángel Sánchez-FernándezRaimon SanmartíAntonio Fernández-NebroMercedes Alperi-LópezJesús TorneroAna María OrtizCarlos Marras Fernández-CidNúria PalauWenjing PanMiranda Byrne-SteeleDmytro StarenkiDaniel WeberIvan Rodriguez-NunezJian HanRichard M MyersSara MarsalAntonio Julià

Published in: Genome biology (2024)

Simultaneous sequencing of the seven chains of the human AIRR reveals novel features associated with the disease and clinically relevant phenotypes, including response to therapy. These findings show the unique potential of AIRR to address precision medicine in immune-related diseases.

Keyphrases

rheumatoid arthritis
endothelial cells
single cell
disease activity
stem cells
induced pluripotent stem cells
ankylosing spondylitis
mesenchymal stem cells
idiopathic pulmonary fibrosis
data analysis
chemotherapy induced