IL-7 is a Key Driver Cytokine in Spondyloarthritis?

Rafaela Silva Guimaraes Gonçalves Ângela Luzia Branco Pinto Duarte

Published in: Journal of immunology research (2019)

The rationale for a type 17 signature in the pathogenesis of spondyloarthritis (SpA) has been increasing and being ratified in studies recently. IL-7 is a cytokine whose ability to stimulate IL-17 production in both innate and adaptive immunity cells has made it a promising target not only for a better understanding of the disease as well as an important potential therapeutic target in patients with SpA.

Keyphrases

ankylosing spondylitis
immune response
induced apoptosis
disease activity
rheumatoid arthritis
systemic lupus erythematosus
oxidative stress
endoplasmic reticulum stress
cell proliferation
case control
human health
pi k akt