The role of inflammation in driving left ventricular remodeling in a pre-HFpEF model.
Maria L Loredo-MendozaIsrael Ramirez-SanchezMoises Muratt Bustamante-PozoMarcos AyalaViridiana NavarreteAlejandra Garate-CarrilloBruce R ItoGuillermo CeballosJeffrey OmensFrancisco VillarrealPublished in: Experimental biology and medicine (Maywood, N.J.) (2020)
The incidence of HFpEF continues to increase and ∼2/3 of the patient population are post-menopausal women. Unfortunately, most studies focus on the use of male animal models of remodeling. In this study, however, using female rats to set a model of pre-HFpEF, we provide insights to possible mechanisms that contribute to HFpEF development in humans that will lead us to a better understanding of the underlying pathophysiology of HFpEF.